Mesoporous materials modified by aptamers and hydrophobic groups assist ultra-sensitive insulin detection in serum.
نویسندگان
چکیده
A novel mesoporous material modified with both insulin-binding-aptamers and hydrophobic methyl groups is synthesized. With rationally designed pore structures and surface chemistry, this material is applied in sample pre-treatment for ELISA, and enables the quantification (0.25-5 pg ml(-1)) of insulin in serum, 30-fold enhancement of the limit-of-detection compared to the commercial ELISA kit.
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عنوان ژورنال:
- Chemical communications
دوره 51 71 شماره
صفحات -
تاریخ انتشار 2015